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Elevation of brain magnesium with Swiss chard and buckwheat extracts in an animal model of reduced magnesium dietary intake

by Desiree Cobb-Olori | Nov 4, 2021

Bassem F. El-Khodor, Karma James, Qing Chang, Wei Zhang, Yvette R. Loiselle, Chinmayee Panda & Taleen Hanania Nutritional Neuroscience. 2022 DOI: 10.1080/1028415X.2021.1995119, https://doi.org/10.1080/1028415X.2021.1995119 Objectives: Inadequate dietary magnesium...

Use of Phenotypic Screening in Mice in the Development of a Novel Non-D2-Receptor-Targeting Drug for the Treatment of Schizophrenia

by Desiree Cobb-Olori | Dec 9, 2020

E. Leahy, M. Varney and D. Brunner SEP-363856, a novel, first-in-class drug treatment being developed by Sunovion Pharmaceuticals, showed robust therapeutic effects in patients diagnosed with schizophrenia across a broad range of disabling symptoms including positive,...

Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex

by Desiree Cobb-Olori | Oct 8, 2020

Theilmann, et. al, Neuropharmacology. 2020 Theilmann, W, Gericke, B,Schidlitzki, A, Anjum, S, Borsdorf, S, Harries, T, Roberds, S.L.,Aguiar, D, Brunner, D, Leiser, S, Song, D, Fabbro, D, Hillmann, P, Wymann, M, Loscher, W.Neuropharmacology....

Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington’s Disease

by Desiree Cobb-Olori | Aug 24, 2020

DOI: 10.3233/JHD-190389 Afshin Ghavami 1, Michael Olsen 1, Mei Kwan 1, Jose Beltran 1, John Shea 1, Sylvie Ramboz 1, Wenzhen Duan 2, Daniel Lavery 3, David Howland 3, Larry...

Mouse model systems of autism spectrum disorder: Replicability and informatics signature

by Desiree Cobb-Olori | Aug 16, 2020

Kabitzke, P, Morales, D, He, D, Cox, K, Sutphen, J, Thiede, L, Sabath, E, Hanania, T, Biemans, B, Brunner, D. Genes, Brain and Behavior. 2020;e12676. DOI: 10.1111/gbb.12676 Phenotyping mouse model systems of human disease has proven to be a difficult task, with...
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