Chemical Induction Models for Preclinical Research
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Chemical Induction Models
Chemical-induced seizure models are extensively used to evaluate potential anticonvulsant compounds. Among these, the PTZ (Pentylenetetrazol)-induced seizure model is a highly validated and reproducible system that enables detailed characterization of seizure onset, progression, and severity. By antagonizing GABA_A receptors, PTZ triggers seizures resembling critical features of human epilepsy, thus serving as a translationally relevant platform for screening investigational drug candidates
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Latency to First Twitch
Latency to Death
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Acute injection of valproate (400 mg/kg; IP) increases the latency to seizures (twitch, clonic/tonic and tonic seizures) following PTZ injection. Treatment with valproate Increases survival of the mice atter PTZ Injection