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Delta 7 Model: A Rapidly Progressing SMA Model
The Δ7SMN+/+;SMN2+/+;Smn-/- neonatal mouse model also referred at Delta 7 is widely used for screening potential therapies. Delta 7 mice have a life span of 17 days with a median survival of 12 days. Rapidly after birth, Delta 7 animals display loss of body weight and motor strength. Due to this rapid symptom progression, PsychoGenics developed motor dysfunction behavioral tests and drug delivery methods to enable treatment as early as birth, including ICV drug administration. In addition, genotyping is performed in less than 24 hours.