Preclinical Seizure
Models
Services
Services
Preclinical Rodent Models of Seizure
To better evaluate your drug product, PsychoGenics employs preclinical seizure models that include Fragile X (FMR1) KO mice, 29SVEV mice, and CF1 mice. We use various methods to induce and measure seizures including our industry leading EEG capabilities:
Chemical-Induced Seizures
Mice are injected with PTZ and observed for 30 minutes. Seizures are ranked on a scale from 0 (no seizure) to 6 (severe seizure).
Electroshock-Induced Seizures
PsychoGenics offers both MES and 6Hz electroshock-induced seizures. Seizure severity or immobility time is measured following corneal stimulation.
Amygdala-Induced Kindling
The amygdala-induced kindling model in rats is a classic and widely used model for studying chronic epilepsy and epileptogenesis.
Harmaline-Induced Tremors
Essential Tremor (ET) is the most common movement disorder, characterized by involuntary, rhythmic shaking that primarily affects the hands and arms. It is a progressive neurological condition often linked to abnormal synchronization of brain activity, particularly in the cerebellum.