Electroshock-Induced Seizures for Preclinical Research 

Electroshock-Induced Seizures

Electroshock-induced seizure models, such as the Maximal Electroshock Seizure (MES) and the 6 Hz Psychomotor Seizure models, are fundamental preclinical assays. They involve delivering a precisely controlled electrical stimulus to animals (typically mice or rats) to induce acute, reproducible seizures. The primary goal of using these electrically-induced models is to efficiently test and characterize the spectrum and efficacy of novel anti-seizure drugs (ASDs) against seizure types that correspond to various human epilepsies. They are often used side-by-side because they model different types of human epileptic seizures.

Acute injection of Valproate dose dependently decreases immobility following 6Hz at 32mA in male CF-1 mice.