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The SmartCube Platform: Use of Phenotypic Screening in Mice with Machine Learning to Identify Novel Antipsychotic Compounds

by Desiree Cobb-Olori | Aug 24, 2023

Validated Phenotypic Approach to Neuropsychiatric Drug Discovery

by Desiree Cobb-Olori | Mar 1, 2019

Leahy E Drug Development & Delivery March 2019 Vol 19 No 2: 46-49. At the recent American College of Neuropsychopharmacology (ACNP) meeting, Sunovion Pharmaceuticals and PsychoGenics Inc. announced positive Phase 2 results for SEP-363856, a novel, first-in-class...

Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.

by Desiree Cobb-Olori | Sep 26, 2015

doi: 10.1371/journal.pone.0134572. eCollection 2015. Brunner D., Kabitzke P., He D., Cox K., Thiede L., Hanania T., He D., Sabath E., Alexandrov V., Saxe M., Peles E., Mills A., Spooren W., Ghosh A., Feliciano P., Benedetti M., Clayton AL., Biemans B. PLoS One 2015...

High-throughtput analysis of behavior for drug discovery

by Desiree Cobb-Olori | Mar 5, 2015

Alexandrov V, Brunner D, Hanania T, Leahy E European Journal of Pharmacology.750 2015 82-89 DOI: 10.1016/j.ejphar.2014.11.047 Drug testing with traditional behavioral assays constitutes a major bottleneck in the development of novel therapies. PsychoGenics developed...

Insights into the Structural Determinants Required for High Affinity Binding of Chiral Cyclopropane-Containing Ligands to α4β2-Nicotinic Acetylcholine Receptors; An Integrated Approach to Behaviorally Active Nicotinic Ligands.

by Desiree Cobb-Olori | Oct 25, 2012

Zhang HK, Eaton JB, Yu LF, Nys M, Mazzolari A, van Elk R, Smit AB, Alexandrov V, Hanania T, Sabath E, Fedolak A, Brunner D, Lukas RJ, Vistoli G, Ulens C, Kozikowski AP. J.Med. Chem., 2012 55(18), pp 8028-8037
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