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The GBA1 D409V Mutation Exacerbates Synuclein Pathology to Differing Extents in two Alpha-Synuclein Models

by marcbacon | Aug 24, 2022

Heterozygous mutations in the GBA1 gene – encoding lysosomal glucocerebrosidase (GCase) – are the most common genetic risk factors for Parkinson’s disease (PD). Experimental evidence suggests a correlation between decreased GCase activity and accumulation of...

Phenotypic Characterization of Recessive Gene Knockout Rat Models of Parkinson’s Disease

by marcbacon | Jun 24, 2014

Kuldip D. Dave, Shehan De Silv, Niketa P. Sheth, Sylvie Ramboz, Melissa J. Beck, Changyu Quang, Robert C. Switzer III, Syed O. Ahmad, Susan M. Sunkin, Dan Walker, Xiaoxia Cui, Daniel A. Fisher, Aaron M. McCoy, Kevin Gamber, Xiaodong Ding, Matthew S. Goldberg, Stanley...
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