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Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington’s Disease

by marcbacon | Aug 24, 2020

DOI: 10.3233/JHD-190389 Afshin Ghavami 1, Michael Olsen 1, Mei Kwan 1, Jose Beltran 1, John Shea 1, Sylvie Ramboz 1, Wenzhen Duan 2, Daniel Lavery 3, David Howland 3, Larry...

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

by marcbacon | Jul 9, 2019

Zeitler B, Froelich S, Marlen K, Shivak D.A, Yu Q, Li D, Pearl J.R, Miller J.C, Zhang L, Paschon D.E, Hinkley S.J, Ankoudinova I, Lam S, Guschin D, Kopan L, Cherone J.M, Nguyen B.H.O, Qiao G, Ataei Y, Mendel M.C, Amora R, Surosky R, Laganiere J, Vu B.J , Narayanan A,...

Large-scale phenome analysis defines a behavioral signature for Huntington’s disease genotype in mice.

by marcbacon | Nov 26, 2016

Alexandrov V, Brunner D, Menalled LB, Kudwa A, Watson-Johnson J, Mazzella M, Russel I, Ruiz MC, Torello J, Sabath E, Sanchez A, Gomez M, Filipov I, Cox K, Kwan M, Ghavami A, Ramboz S, Lager B2, Wheeler VC, Aaronson J, Rosinski J, Gusella JF, MacDonald ME, Howland D,...

Animal Models of Huntington’s Disease for Translation to the Clinic: Best Practices. Movement Disorders

by marcbacon | Aug 26, 2014

Menalled L & Brunner D. 29(11): 1375-90 2014

Regional Vulnerability in Huntington’s disease: fMRI-guided Molecular Analysis in Patients and a Mouse Model of disease

by marcbacon | Apr 1, 2013

Moreno H, Lewandowski N, Bordelon Y, Brickman A, Angulo S, Khan U, Muraskin J, Griffith E, Wasserman P, Menalled L, Vonsattel J.P, Marder K, Small S.A Although the huntingtin gene is expressed in brain throughout life, phenotypically Huntington’s disease (HD)...
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