by Desiree Cobb-Olori | Aug 12, 2026
Autism spectrum disorders (ASDs) describe a broad category of neurodevelopmental disorders that can pose challenges to an individual’s health over a lifetime. The severity and specificity of clinical features of ASDs can vary from individual to individual,...
by Desiree Cobb-Olori | Jun 24, 2025
Approximately 2% of individuals with ASD carry mutations in the Shank3 gene, which plays a crucial role in organizing neuronal connections. Shank3B-KO mice, developed by Professor Guoping Feng at MIT, harbor a deletion of exons 13-16 of the PDZ domains...
by Desiree Cobb-Olori | Jan 28, 2025
Fragile X Syndrome (FXS) is a genetic disorder caused by a CGG expansion in the Fmr1 gene. This condition tends to affect males more severely, while females often present a mosaic pattern of effects. Symptoms of FXS include: delayed crawling and walking, speech...
by Desiree Cobb-Olori | Aug 16, 2020
Kabitzke, P, Morales, D, He, D, Cox, K, Sutphen, J, Thiede, L, Sabath, E, Hanania, T, Biemans, B, Brunner, D. Genes, Brain and Behavior. 2020;e12676. DOI: 10.1111/gbb.12676 Phenotyping mouse model systems of human disease has proven to be a difficult task, with...
by Desiree Cobb-Olori | Sep 26, 2015
doi: 10.1371/journal.pone.0134572. eCollection 2015. Brunner D., Kabitzke P., He D., Cox K., Thiede L., Hanania T., He D., Sabath E., Alexandrov V., Saxe M., Peles E., Mills A., Spooren W., Ghosh A., Feliciano P., Benedetti M., Clayton AL., Biemans B. PLoS One 2015...
