Characterization of a Mouse Model of Parkinson’s Disease

The Thy-1-α-synuclein mouse model of Parkinson’s disease is a transgenic mouse model that over-expresses wild-type human alpha-synuclein under the Thy1 promoter in neurons. The model exhibits dopaminergic neuronal loss, alpha-synuclein aggregates, neuroinflammation,...

Characterization of a Mouse Model of CMT2E

The below data was made possible by CMTA, the Charcot-Marie-Tooth Association. Charcot-Marie-Tooth (CMT) disorders are a family of related disorders that produce progressive distal neuropathies, presenting significant challenges for patients and society. CMT2E is...

Characterization of a Rat Model of CMT2A

The below data was made possible by CMTA, the Charcot-Marie-Tooth Association. Charcot-Marie-Tooth (CMT) disorders are a family of related disorders that produce progressive distal neuropathies, presenting significant challenges for patients and society. CMT2A is...