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Our Animal Models of Alzheimer’s Disease
Our expertise in Alzheimer’s disease models enables us to select the most appropriate models for specific research needs:
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rTg4510 Mouse Model
This inducible tauopathy mouse model, rTg4510, overexpresses human P301L-mutant tau in the forebrain. By utilizing the tetracycline-controlled transactivator (tTA) system, combined with the CaMKII α promoter, this model recapitulates tau pathology observed in Alzheimer’s disease. This model shows cognitive deficits, neuroinflammation, and increased NF-L in plasma and CSF.
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APP/PS1 Double Transgenic Mouse Model
The APP/PS1 double transgenic mouse model overexpresses mutated forms of the genes for human amyloid precursor protein (APPsw) and presenilin 1 (m146L). This model allows us to study the progressive amyloid deposition observed in Alzheimer’s disease, providing insights into the disease’s development.