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A systematic assessment of robustness in CNS safety pharmacology.

Nutritional supplement containing a nuclear fraction of bovine thymus gland increases the circulating levels of spermidine

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Knock-in mouse models of Huntington’s disease.

Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP.

Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice.

Juvenile 5HT(1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT(1A) receptor activation.

Application of triple-probe microdialysis for fast PK/PD evaluation of dopamimetic activity of drug candidates in the rat brain.

Striatal plasticity at the network level. Focus on adenosine A(2A) and D(2) interactions in models of Parkinson’s Disease.

Effects of the DT-diaphorase inhibitor dicumarol on striatal monoamine levels in L-DOPA and L-deprenyl pre-treated rats.

Stress-induced hyperthermia and anxiety: pharmacological validation.

In need of high-throughput behavioral systems.

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