Behavior-based screening as an approach to polypharmacological ligands.
Brunner, D.; Alexandrov, V.; Chandrasekhar, J.; Hanania, T.; Caldarone, B.; Lowe, D.; Schneider J. In Polypharmacology in Drug Discovery, Peters,...
HD mouse models reveal clear deficits in learning to perform a simple instrumental response. PLoS Currents: Huntington Disease.
Oakeshott, S., Port, R. G., Cummins-Sutphen, J., Watson-Johnson, J., Ramboz, S., Park, L., Howland, D., and Brunner, D.
Discovery of Isoxazole Analogs of Sazetidine-A as Selective alpha4 beta2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists for the Treatment of Depression,
Liu, J., Yu, L. F., Eaton, J. B., Caldarone, B., Cavino, K., Ruiz, C., Terry, M., Fedolak, A., Wang, D.,...
Comparative psychology and the grand challenge of drug discovery in psychiatry and neurodegeneration,
Brunner, D., Balci, F., and Ludvig, E. A. Behav Processes 2011 89, 187-195
Effect of the rd1 mutation on motor performance in R6/2 and wild type mice [Internet]. Version 28.
Liliana M.; El-Khodor B F.; Hornberger M.; Park, Larry; Howland, David; Brunner D. PLoS Currents: Huntington Disease. 2011 Nov 29...
Impulsive action and impulsive choice are mediated by distinct neuropharmacological substrates in rat
Paterson N.E., Wetzler C., Hackett A., Hanania T. Int J Neuropsychopharmacol 2011
Rapid, computer vision-enabled murine screening system identifies neuropharmacological potential of two new mechanisms.
Steven L Roberts, Filippov I.; Alexandrov V.; Hanania T.; Brunner D. Frontiers in Neuropharmacology.
Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone.
Paterson, N. E.; Ricciardi, J.; Wetzler, C.; Hanania, T. Neurosci Res 2011, 69, 41-50.
Mephedrone, compared to MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and serotonin levels in nucleus accumbens of awake rats.
Kehr, J.; Ichinose, F.; Yoshitake, S.; Goiny, M.; Sievertsson, T.; Nyberg, F.; Yoshitake, T. Br J Pharmacol
Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease.
Oakeshott, S.; Balci, F.; Filippov, I.; Murphy, C.; Port, R.; Connor, D.; Paintdakhi, A.; Lesauter, J.; Menalled, L.; Ramboz, S.;...