Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington’s disease: zQ175
Menalled L, Kudwa A, Miller S, Fitzpatrick J, Watson-Johnson J, Keating N, Ruiz M, Mushlin R, Alosio B, McConnell K,...
Insights into the Structural Determinants Required for High Affinity Binding of Chiral Cyclopropane-Containing Ligands to α4β2-Nicotinic Acetylcholine Receptors; An Integrated Approach to Behaviorally Active Nicotinic Ligands.
Zhang HK, Eaton JB, Yu LF, Nys M, Mazzolari A, van Elk R, Smit AB, Alexandrov V, Hanania T, Sabath...
Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity .
S. Stefanie, H Bettina, Nilges M, Schroeder S, Hoelich A, Keletzl H, Spooren W, Ostrowitzki S, Hanania T, Sendtner M,...
Prediction of Death in the SMNΔ Mouse Model of Spinal Muscular Atrophy: Insight into Disease Stage and Progression. Journal of Neuroscience Methods.
El-Khodor BF, Cirillo K, Beltran JA, Mushlin R, Winberg ML, Charney R, Chomicova O, Marino T, Ramboz S.
Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Ä7 SMA KO Mouse Model of Spinal Muscular Atrophy.
Chen PC, Gaisina IN, El-Khodor BF, Ramboz S, Makhortova NR, Rubin LL, Kozikowski AP. ACS Chem Neurosci. 2012 Jan 18;3(1):5-11.
Effect of the rd1 mutation on motor performance in R6/2 and wild type mice. PLoS Currents Huntington Disease.
Menalled, L., El-Khodor, B. F., Hornberger, M., Park, L., Howland, D., and Brunner, D.
Identification of Novel alpha4 beta2-Nicotinic Acetylcholine Receptor (nAChR) Agonists Based on an Isoxazole Ether Scaffold that Demonstrate Antidepressant-like Activity. Journal of medicinal chemistry.
Yu, L. F., Tuckmantel, W., Eaton, J. B., Caldarone, B., Fedolak, A., Hanania, T., Brunner, D., Lukas, R. J., and...
Behavior-Based Screening as an Approach to Polypharmacological Ligands, in Polypharmacology in Drug Discovery.
Brunner, D., Alexandrov, V., Caldarone, B., Hanania, T., Lowe, D., Schneider, J., and Chandrasekhar, J. (Peters, J.-U., Ed.), pp 301-309,...
R6/2 Huntington’s disease Mice Develop Early and Progressive Abnormal Brain Metabolism and Seizures.
Efrain Cepeda-Prado, Susanna Popp, Usman Khan, Dimitre Stefanov, Jorge Rodrguez, Liliana Menalled, Diana Dow-Edwards, Scott Small, and Herman Moreno JN-RM-0388-12R1
Caspase-6 activity in a BAC HD mouse modulates steady state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
Juliette Gafni, Theodora Papanikolaou, Francesco DeGiacomo, Jennifer Holcomb, Sylvia Chen, Menalled L.; Kudwa A.; Jon Fitzpatrick, Miller S.; Ramboz S.;...