Large-scale phenome analysis defines a behavioral signature for Huntington’s disease genotype in mice.
Alexandrov V, Brunner D, Menalled LB, Kudwa A, Watson-Johnson J, Mazzella M, Russel I, Ruiz MC, Torello J, Sabath E,...
In Vivo Phenotypic Drug Discovery: Applying a Behavioral Assay to the Discovery and Optimization of Novel Antipsychotic Agents.
Shao L, Campbell U, Fang K, Powell AN, Campbell JE, Jones PG, Hanania T, Alexandrov V, Morganstern I, Sabath E,...
Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.
doi: 10.1371/journal.pone.0134572. eCollection 2015. Brunner D., Kabitzke P., He D., Cox K., Thiede L., Hanania T., He D., Sabath E., Alexandrov...
High-throughtput analysis of behavior for drug discovery
Alexandrov V, Brunner D, Hanania T, Leahy E European Journal of Pharmacology.750 2015 82-89 DOI: 10.1016/j.ejphar.2014.11.047 Drug testing with traditional behavioral...
Effect of a novel, orally active matrix metalloproteinease-2 and-9 inhibitor in spinal and trigeminal rat models of neuropathic pain
To study the effect of a novel matrix metalloproteinease-2 (MMP-2) and MMP–9 inhibitor, AQU-118, on mechanical allodynia in the spinal...
Animal Models of Huntington’s Disease for Translation to the Clinic: Best Practices. Movement Disorders
Menalled L & Brunner D. 29(11): 1375-90 2014
Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington’s Disease
Menalled LB, Kudwa A, Oakeshott S, Farrar A, Paterson N, Filippov I, Miller S, Kwan M, Olsen M, Beltran J,...
Phenotypic characterization of recessive gene knockout rat models of Parkinson’s disease
Kuldip D. Dave, Shehan De Silv, Niketa P. Sheth, Sylvie Ramboz, Melissa J. Beck, Changyu Quang, Robert C. Switzer III,...
High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington’s Disease.
Balci F, Oakeshott S, Shamy J.S., El-Khodor B.F., Filippov I, Mushlin R, Port R, Connor D, Paintdakhi A, Menalled L,...
Regional vulnerability in Huntington’s disease: fMRI-guided molecular analysis in patients and a mouse model of disease
Moreno H, Lewandowski N, Bordelon Y, Brickman A, Angulo S, Khan U, Muraskin J, Griffith E, Wasserman P, Menalled L,...