The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models
Heterozygous mutations in the GBA1 gene – encoding lysosomal glucocerebrosidase (GCase) – are the most common genetic risk factors for...
Elevation of brain magnesium with Swiss chard and buckwheat extracts in an animal model of reduced magnesium dietary intake
Bassem F. El-Khodor, Karma James, Qing Chang, Wei Zhang, Yvette R. Loiselle, Chinmayee Panda & Taleen Hanania Nutritional Neuroscience. 2022...
Use of Phenotypic Screening in Mice in the Development of a Novel Non-D2-Receptor-Targeting Drug for the Treatment of Schizophrenia
E. Leahy, M. Varney and D. Brunner SEP-363856, a novel, first-in-class drug treatment being developed by Sunovion Pharmaceuticals, showed robust...
Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex
Theilmann, W, Gericke, B,Schidlitzki, A, Anjum, S, Borsdorf, S, Harries, T, Roberds, S.L., Aguiar, D, Brunner, D, Leiser, S, Song,...
Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington’s Disease
DOI: 10.3233/JHD-190389 Afshin Ghavami 1, Michael Olsen 1, Mei Kwan 1, Jose Beltran 1, John Shea 1, Sylvie Ramboz 1, Wenzhen Duan 2, Daniel Lavery 3, David Howland 3, Larry C Park 3 Abstract Background: Huntington’s disease (HD) is a progressive...
Mouse model systems of autism spectrum disorder: Replicability and informatics signature
Kabitzke, P, Morales, D, He, D, Cox, K, Sutphen, J, Thiede, L, Sabath, E, Hanania, T, Biemans, B, Brunner, D....
Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals
Abstract Over the last two decades, awareness of the negative repercussions of flaws in the planning, conduct and reporting of...
ANAVEX®2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndrome
Kaufmann W E, Sprouse J, Rebowe N, Hanania T, Klamer D, Missling C U Pharmacol Biochem Behav. 2019, December 187:172796....
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease
Zeitler B, Froelich S, Marlen K, Shivak D.A, Yu Q, Li D, Pearl J.R, Miller J.C, Zhang L, Paschon D.E,...