Preclinical Drug Development Research & Resources

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Therapeutic Areas

Poster

Evaluation of the abuse liability of gabapentin and duloxetine in male and female rats using two approaches: intravenous self-administration and conditioned place preference

Poster

Evaluation of the Abuse Liability of Oxycodone in Male and Female Rats Using Two Approaches: Intravenous Self-Administration and Conditioned Place Preference

Publication

Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals

Poster

The SmartCube Platform: Use of Phenotypic Screening in Mice with Machine Learning to Identify Novel Antipsychotic Compounds

Poster

The SmartCube Platform: Use of Phenotypic Screening in Mice with Machine Learning to Identify Novel Antipsychotic Compounds

Publication

Validated Phenotypic Approach to Neuropsychiatric Drug Discovery

Publication

Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.

Publication

High-throughtput analysis of behavior for drug discovery

Publication

High-throughtput analysis of behavior for drug discovery

Publication

Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington’s Disease

Publication

Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain

Poster

In Vivo PK, Side Effect Profile, and Efficacy of Multiple Classes of Analgesics in Rats

Publication

Elevation of brain magnesium with Swiss chard and buckwheat extracts in an animal model of reduced magnesium dietary intake

Publication

Anxiolytic effects of lamotrigine and JZP-4 in the elevated plus maze and in the four plate conflict test.

Podcast

Beyond Biotech podcast 23: World Antimicrobial Awareness Week, PsychoGenics

Publication

Identification of Novel alpha4 beta2-Nicotinic Acetylcholine Receptor (nAChR) Agonists Based on an Isoxazole Ether Scaffold that Demonstrate Antidepressant-like Activity. Journal of medicinal chemistry.

Publication

Discovery of Isoxazole Analogs of Sazetidine-A as Selective alpha4 beta2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists for the Treatment of Depression,

Publication

Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380.

Publication

The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition.

Publication

The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties.

Poster

The SmartCube Platform: Use of Phenotypic Screening in Mice with Machine Learning to Identify Novel Antipsychotic Compounds

Publication

In Vivo Phenotypic Drug Discovery: Applying a Behavioral Assay to the Discovery and Optimization of Novel Antipsychotic Agents.

Publication

Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer’s Disease

Poster

Phenotyping of the TDP-43 ΔNLS mouse model of ALS

Poster

Characterization of a SOD1 Rat Model of ALS: Behavior and Electrophysiology

Blog

Phenotyping of a TDP-43 Mouse Model of ALS

Publication

Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD

Publication

Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity .

Blog

Characterization of The R6/1 Mouse Model of Huntington’s Disease

Publication

Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington’s Disease

Publication

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

Publication

Large-scale phenome analysis defines a behavioral signature for Huntington’s disease genotype in mice.

Publication

Animal Models of Huntington’s Disease for Translation to the Clinic: Best Practices. Movement Disorders

Publication

Regional vulnerability in Huntington’s disease: fMRI-guided molecular analysis in patients and a mouse model of disease

Publication

Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington’s disease: zQ175

Publication

Effect of the rd1 mutation on motor performance in R6/2 and wild type mice. PLoS Currents Huntington Disease.

Publication

Caspase-6 activity in a BAC HD mouse modulates steady state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.

Publication

HD mouse models reveal clear deficits in learning to perform a simple instrumental response. PLoS Currents: Huntington Disease.

Publication

Comprehensive behavioral testing in the R6/2 mouse model of Huntington’s disease shows no benefit from CoQ10 or minocycline.

Blog

Characterization of a Mouse Model of Parkinson’s Disease

Poster

Characterization of a Model of Parkinson’s Disease Using Synthetic α-Synuclein Inoculation to Evaluate Motor Function, Synucleinopathy, and Dopaminergic Neurotransmission.

Publication

The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models

Publication

Phenotypic characterization of recessive gene knockout rat models of Parkinson’s disease

Publication

Prediction of Death in the SMNΔ Mouse Model of Spinal Muscular Atrophy: Insight into Disease Stage and Progression. Journal of Neuroscience Methods.

Publication

Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Ä7 SMA KO Mouse Model of Spinal Muscular Atrophy.

Publication

Mouse model systems of autism spectrum disorder: Replicability and informatics signature

Publication

Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.

Publication

ANAVEX®2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndrome

Poster

Phenotyping of the TDP-43 ΔNLS mouse model of ALS

Poster

Characterization of a SOD1 Rat Model of ALS: Behavior and Electrophysiology

Blog

Phenotyping of a TDP-43 Mouse Model of ALS

Publication

Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD

Publication

Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity .

Blog

Characterization of a Mouse Model of CMT2E

Blog

Characterization of a Rat Model of CMT2A

Blog

Characterization of a Mouse and Rat Model of CMT1A

Publication

Myelinated axons fail to develop properly in a genetically authentic mouse model of Charcot-Marie-Tooth disease type 2E

Publication

Prediction of Death in the SMNΔ Mouse Model of Spinal Muscular Atrophy: Insight into Disease Stage and Progression. Journal of Neuroscience Methods.

Publication

Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Ä7 SMA KO Mouse Model of Spinal Muscular Atrophy.

Poster

In vivo PK, side effect profile, and efficacy of multiple clinically used compounds in female and male rats

Poster

Comparison of rat models of vascular headache and trigeminal sensitization in male and female rats.

Poster

Elucidating Pain-Related Activity in the Eeg From the Rat Spinal Nerve Ligation Model (SNL) Of Neuropathic Pain

Poster

Evaluation of Behavioral Pain Phenotype in the Rat Monoiodoacetateand Medial Meniscal Tear Models of Osteoarthritis Pain

Poster

Evaluation of Behavioral Pain Phenotype and Optimization of the Rat Paclitaxel and Oxaliplatin Models of Chemotherapy-Induced Peripheral Neuropathy

Poster

In Vivo PK, Side Effect Profile, and Efficacy of Multiple Classes of Analgesics in Rats

Poster

The NIH HEAL Initiative Preclinical Screening Platform for Pain (PSPP) efforts to validate rodent models of pain and migraine

Poster

The NIH HEAL Initiative Preclinical Screening Platform for Pain (PSPP) Validation of the Monoiodoacetate (MIA) Model of Osteoarthritis Pain in the Rat

Poster

The NIH HEAL Initiative Preclinical Screening Platform for Pain Efforts to Validate Two Models of Chemotherapy-Induced Painful Neuropathy in the Rat

Poster

Efforts to Accelerate Development of Non-Opioid, Non-Addictive Pain Therapeutics Within the NIH HEAL Initiative Preclinical Screening Platform for Pain and Validation Examples

Poster

Characterization of the Rat MonoiodoacetateModel of Osteoarthritis: Evoked and Non-evoked Pain Response Assessments

Poster

Characterization and optimization of rat models of osteoarthritis pain to profile novel assets in support of the NIH HEAL Initiative Preclinical Screening Platform for Pain (PSPP)

Publication

Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain

Publication

Effect of a novel, orally active matrix metalloproteinease-2 and-9 inhibitor in spinal and trigeminal rat models of neuropathic pain

Poster

Model Development of a T8 Rat Contusion Model: Different Lesion Severities Elicited Distinct Locomotor and Sensory Profiles.

Poster

Longitudinal Profiling of Vocalizations and the Effect of an ASO on the Ube3a Phenotype

Poster

In vivo PK, side effect profile, and efficacy of multiple clinically used compounds in female and male rats

Poster

Phenotyping of the TDP-43 ΔNLS mouse model of ALS

Poster

Standardized Locomotor and Sensory behavior changes in a graded contusive spinal cord injury model

Poster

Characterization of a SOD1 Rat Model of ALS: Behavior and Electrophysiology

Poster

Evaluation of the abuse liability of gabapentin and duloxetine in male and female rats using two approaches: intravenous self-administration and conditioned place preference

Poster

Comparison of rat models of vascular headache and trigeminal sensitization in male and female rats.

Publication

A systematic assessment of robustness in CNS safety pharmacology

Publication

ANAVEX®2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndrome

Publication

Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex

Publication

ANAVEX®2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndrome

Publication

Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex

Poster

Model Development of a T8 Rat Contusion Model: Different Lesion Severities Elicited Distinct Locomotor and Sensory Profiles.

Poster

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Therapeutic Areas

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