Parkinson's disease (PD) is a neurodegenerative disorder mainly affecting the motor system, resulting in progressive death of dopamine-generating cells in the substantia nigra pars compacta. Beside the most obvious symptoms movement-related symptoms such as shaking, rigidity, slowness of movement and gait, patients develop non-motor symptoms, afflicting personality and behavior (depression, anxiety, apathy), as well disturbances in cognitive function. The etio-pathogenesis of the disease is not fully explored as the majority of patient cases are sporadic; however mutations in alpha-synuclein causing abnormally aggregated ( “Lewy bodies”), and mitochondrial genes like Pink-1 or DJ-1 have been linked to the pathology. Certain toxin exposure also increases (different pesticides e.g. rotenone) the risk.
Genetic and chemical induced lesion disease models are available to study the disease mechanisms and for drug screening.
To view phenotypic data, click on any of the experimental tests below: