Selected Publication with PGI Scientists as Authors

                                                  Paterson NE, Fedolak A, Olivier B, Hanania T, Ghavami A, Caldarone B (2010) Mar 25. Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents. Pharmacol Biochem Behav. 95(4):449-456.

                                                  Paterson NE, Iwunze M, Davis SF, Malekiani SA, Hanania T. J Neurosci Methods. (2010) Feb 10. Comparison of the predictive validity of the mirror chamber and elevated plus maze tests in mice. 188: 62–70

                                                  Paterson NE, Hanania T.(2010) Mar 17. The modified Geller-Seifter test in rats was insensitive to GABAB receptor positive modulation or blockade, or 5HT1A receptor activation. Behav Brain Res. 208(1):258-64 In Press

                                                  Paterson NE, Malekiani SA, Foreman MM, Olivier B, Hanania T. (2009) Aug 15. Pharmacological characterization of harmaline-induced tremor activity in mice. Eur J Pharmacol. 616(1-3):73-80

                                                  Foreman MM, Hanania T, Eller M (2009). Anxiolytic effects of lamotrigine and JZP-4 in the elevated plus maze and in the four plate conflict test. Eur J Pharmacol. 14;602(2-3):316-20. Epub 2008 Nov 17.

                                                  Balci F, Gallistel CR, Allen BD, Frank KM, Gibson JM, Brunner D (2008). Acquisition of peak responding: What is learned? Behav Processes. Oct 4. [Epub ahead of print]

                                                  El-Khodor BF, Edgar N, Chen A, Winberg ML, Joyce C, Brunner D, Suárez-Fariñas M, Heyes MP (2008). Identification of a battery of tests for drug candidate evaluation in the SMNDelta7 neonate model of spinal muscular atrophy Exp Neurol. 212(1):29-43 .

                                                  Day M, Balci F, Wan HI, Fox GB, Rutkowski JL, Feuerstein G (2008). Cognitive endpoints as disease biomarkers: optimizing the congruency of preclinical models to the clinic. Curr Opin Investig Drugs. 9(7):696-706 .

                                                  Balci, F., Papachristos, E. B., Gallistel, C.R., Brunner, D., Gibson, J., & Shumyatsky, G. P. (2008). Interval-Timing in the Genetically Modified Mouse: A Simple Paradigm. Genes, Brain, and Behavior, 7, 373-384 .

                                                  Foreman MM, Hanania T, Stratton SC, Wilcox KS, White HS, Stables JP, Eller M (2008). In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity. Pharmacol Biochem Behav. 89(4):523-534 .

                                                  Breuer ME, Chan JS, Oosting RS, Groenink L, Korte SM, Campbell U, Schreiber R, Hanania T, Snoeren EM, Waldinger M, Olivier B (2008). The triple monoaminergic reuptake inhibitor DOV 216,303 has antidepressant effects in the rat olfactory bulbectomy model and lacks sexual side effects. Eur Neuropsychopharmacol. 18(12):908-916 .

                                                  Vinkers CH, van Bogaert MJ, Klanker M, Korte SM, Oosting R, Hanania T, Hopkins SC, Olivier B, Groenink L (2008). Translational aspects of pharmacological research into anxiety disorders: the stress-induced hyperthermia (SIH) paradigm. Eur J Pharmacol. 585(2-3):407-425 .

                                                  Balci, F., Ludvig, E. A., Gibson, J., Allen, B., Frank, K., Kaputinski, B. J., & Brunner, D. (2008). Pharmacological manipulations of interval timing using the peak procedure in mice. PsychoPharmacology , 201, 67-80.

                                                  Houghten, R. A., Pinilla, C., Appel, J. R., Giulianotti, M. A., Nefzi, Ostresh, J. M., Dooley, C. T., Maggiora, G. M., Medina Franco, J. L., Brunner, D., & Schneider, J. (2008). Mixture-based synthetic combinatorial libraries: direct in vivo testing, scaffold ranking, and enhanced deconvolution using computational approaches. J. Med. Chem. Perspective. 10, 3-19.

                                                  Roy K, Murtie JC, El-Khodor BF, Edgar N, Sardi SP, Hooks BM, Benoit-Marand M, Chen C, Moore H, O'Donnell P, Brunner D, Corfas G (2007). Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. Proc Natl Acad Sci U S A. 104(19):8131-8136 .

                                                  Kozikowski AP, Gaisina IN, Yuan H, Petukhov PA, Blond SY, Fedolak A, Caldarone B, McGonigle P (2007). Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders. Am Chem Soc. 129(26):8328-8332.

                                                  Cagniard, B., Balsam, P. D., Brunner, D. and Zhuang, X. (2006). Mice with Chronically Elevated Dopamine Exhibit Enhanced Motivation, but not Learning, for a Food Reward. Neuropsychopharmacology (2006) 31, 1362-1370.

                                                  Menalled LB. (2005). Knock-in mouse models of Huntington's disease. NeuroRx. 2(3):465-70 .

                                                  Rothstein JD, Patel S, Regan MR, Haenggeli C, Huang YH, Bergles DE, Jin L, Dykes Hoberg M, Vidensky S, Chung DS, Toan SV, Bruijn LI, Su ZZ, Gupta P, Fisher PB (2005) Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature. 433(7021):73-77 . Behavioral work conducted at PsychoGenics.

                                                  Compan, V., Zhou, M., Grailhe, R., Gazzara, R., Martin, R., Gingrich, J., Dumuis, A., Brunner, D. Bockaert, J., and Hen, R. (2004). Attenuated response to stress- and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. Journal for Neuroscience . 24, 412-419.

                                                  El-Khodor BF, Dimmler MH, Amara DA, Hofer M, Hen R, Brunner D (2004). Juvenile 5HT(1B) receptor knockout mice exhibit reduced pharmacological sensitivity to 5HT(1A) receptor activation. Int J Dev Neurosci. 22(5-6):405-413 .

                                                  Olivier B, Zethof T, Pattij T, van Boogaert M, van Oorschot R, Leahy C, Oosting R, Bouwknecht A, Veening J, van der Gugten J, Groenink L (2003). Stress-induced hyperthermia and anxiety: pharmacological validation. Eur J Pharmacol. 463(1-3):117-132

                                                  Brunner, D. Nestler, E. & Leahy, E. (2002). In need of highthroughput behavioral systems. Drug Discovery Today , 7, S107-112.

                                                  Olivier B, Bouwknecht JA, Pattij T, Leahy C, van Oorschot R, Zethof TJ (2002) GABAA-benzodiazepine receptor complex ligands and stress-induced hyperthermia in singly housed mice. Pharmacol Biochem Behav. 72(1-2):179-188

                                                  Stefansson, H., Sigurdsson, E., Steinthorsdottir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., Chou, T. T., Hjaltason, O., Birgisdottir, B., Jonsson, H., Gudnadottir, V. G., Gudmundsdottir, E., Bjornsson, A., Ingvarsson, B., Ingason, A., Sigfusson, S., Hardardottir, H., Harvey, R. P., Lai, D., Zhou, M., Brunner, D., Mutel, V., Gonzalo, A., Lemke, G., Sainz, J., Johannesson, G., Andresson, T., Gudbjartsson, D., Manolescu, A., Frigge, M. L., Gurney, M. E., Kong, A., Gulcher, J. R., Petursson, H.& Stefansson, K. (2002). Neuregulin 1 and susceptibility to schizophrenia Am J Hum Genet , 71, 877-92.

                                                  Olivier B, Leahy C, Mullen T, Paylor R, Groppi VE, Sarnyai Z, Brunner D (2001). The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics? Psychopharmacology (Berl), 156(2-3):284-290.

                                                  Brunner, D. & Kacelnik, A. (2001). Timing and Foraging: Gibbon's Scalar Expectancy Theory and Optimal Patch Exploitation. Animal Learning and Behavior. 1, 177-190.

                                                  Abner, R., Edwards, T. & Brunner, D. (2001). Pharmacology of Temporal Cognition in Two Mouse Strains. Special issue of the International Journal of Comparative Psychology , 14, 189-210.

                                                  Balci, F., Moore, H. & Brunner, D. (2008). Timing Deficits in Neuropathology In Cognitive Aging: Integrating Models (Ed. By Alisa G Woods). Humana Press. Wagner, L. A., Menalled, L. Gomeniouk, A., Brunner, D., Leavitt, B. R. (2008).Huntington Disease. In: Animal and Translational Models of Behavioral Disorders (Ed. By Robert McArthur and Franco Borsini). Elsevier.