Anxiety

Anxiety encompasses a wide spectrum of disease states. Anxiety disorders include Generalized Anxiety Disorder (GAD), panic disorder, obsessive compulsive disorder (OCD), and Post Traumatic Stress Disorder (PTSD). PGI is currently working to develop tests for OCD and PTSD. Key aspects of these disease states can be recapitulated in rodents in the following tests.

Cognition

Cognition is a complex set of processes, including, attention, learning and memory, and can be defined as the capacity to attend, encode, consolidate, store and retrieve recent and remotely stored fact (semantic) and experience based (episodic) memory. Different brain regions, circuits, and substrates subserve different types of memory. While long-term memory for experiences and fact-based information are generally supported within the medial temporal lobe, short-term memory involves primarily the prefrontal cortex and certain areas of the posterior cortex and the hippocampus. Cognitive impairment is a defining feature of several neurodegenerative and psychiatric disease (e.g. Schizophrenia, Alzheimer's Disease and Huntington Disease).

Depression & Sexual Function

Depression is the most prevalent psychiatric disorder characterized by a state of sadness, despair, discouragement, and hopelessness. Other symptoms may include apathy, withdrawal from social contact, an inability to experience pleasure, changes in appetite and sleep patterns, low energy levels, difficulty concentrating, and thoughts of suicide. Key aspects of these disease states can be recapitulated in rodents in the following tests.

Neurological Disorders

Psychogenics has significant, long standing relationships with several research foundations, focused on Neurodegenerative diseases including CHDI for Huntington's disease, the SMA foundation, and the ALS Association, and has in excess of 50 trained and highly specialised scientists devoted to these disease areas. Psychogenics' behavioural expertise has been crutical in the characterization of appropriate disease models and the establishment of standardized batteries of drug screening protocols that have become the industry standard for accessing potentials compounds and therapeutics.

Psychosis

Schizophrenia is one of the most common psychiatric disorders and affects approximately 1% of the population. It is characterized by positive symptoms such as delusions and hallucinations, and negative symptoms such as incoherent speech, inattention, abnormal social behavior, lack of motivation and reduced sensorimotor function. The following tests have predictive and face validity for antipsychotic drugs.