PsychoGenics offers electrographic (EEG) and behavioral identification of seizures. Many progressive neurologic diseases such as epilepsy require preclinical animal models that slowly develop the disease in order to test interventions at various stages of the disease process. PGI uses synchronized Video-EEG to record spontaneous and chemically-induced seizures using our scalable (multiple animals recorded simultaneously) tethered platforms
We have studied generalized and focal seizures in transgenic models including Tsc1flox/flox-GFAP-Cre (Tsc1GFAPCKO) mice (model of Tuberous Sclerosis), B6.129P2(C)-Mecp2tm1.1Bird/J Het mice (model of Rett syndrome), and Scn8a (Nav1.6-N1768D) and Scn1a (B6(Cg)-Scn1atm1.1Dsf/J) and the kainic acid-induced mesial temporal lobe epilepsy (MTLE) model. Considering the strong construct and etiological validity of the models and the robustness of the seizures, drug screens using genetic models provide strong translation to the clinic.
Tsc1GFAPCKO mouse model of Tuberous Sclerosis
This work was funded by the Tuberous Sclerosis Alliance (TS Alliance) on behalf of the TSC Preclinical Consortium (http://www.tsalliance.org/researchers/preclinical-consortium/). The TSC Preclinical Consortium enables prioritization of potential new treatments based on comparing head-to-head data using consistent animal models and testing procedures. The TS Alliance has licenses to use specific TSC mouse models, including Tsc1GFAPCKO mice, for experiments carried out by the consortium in partnership with academic and commercial entities. For more information about the consortium and the Tsc1GFAPCKO mouse model, please contact the TS Alliance.
Mesial Temporal Lobe Epilepsy (MTLE)
Mecp2- mouse model of Rett