Essential tremors and spontaneous epileptic seizures are disorders common in humans. In order to identify and develop new medications, it is necessary to utilize experimental animal models of epilepsy and tremors. For example, chemically-induced kindling with pentylenetetrazole (PTZ) or electrically-induced seizures can be used a model of epilepsy. Essential tremors, on the other hand, have been difficult to study due to the lack of knowledge of the pathophysiology of tremor and by the lack of a pharmacologically validated preclinical mouse models.
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