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Publication – Depression & Sexual Function

Yu L.F, Tuckmantel W, Eaton J.B, Caldarone B, Fedolak A, Hanania T, Brunner D, Lukas R.J, Kozikowski A.P.
Identification of Novel alpha4 beta2-Nicotinic Acetylcholine Receptor (nAChR) Agonists Based on an Isoxazole Ether Scaffold that Demonstrate Antidepressant-like Activity, Journal of medicinal chemistry. 2012 55, 812-823

Liu J, Yu L.F, Eaton J.B, Caldarone B, Cavino K, Ruiz C, Terry M, Fedolak A, Wang D, Ghavami A, Lowe D.A, Brunner D, Lukas R.J, Kozikowski A.P.
Discovery of Isoxazole Analogs of Sazetidine-A as Selective alpha4 beta2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists for the Treatment of Depression, Journal of medicinal chemistry 2011 54, 7280-7288

Paterson N, Balci F, Campbell U, Olivier B.E, Hanania T.
The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition. J Psychopharmacol 2010.

Caldarone B, Paterson N, Zhou J, Brunner D, Kozikowski A.P, Westphal K.G, Korte-Bouws G.A, Prins J, Korte S.M, Olivier B, Ghavami A.
The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. J Pharmacol Exp Ther 2010, 335, 762-70.

Mason S.S, Baker K.B, Davis K.W, Pogorelov V.M, Malbari M.M, Ritter R, Wray S.P, Gerhardt B, Lanthorn T.H, Savelieva K.V.
Differential sensitivity to SSRI and tricyclic antidepressants in juvenile and adult mice of three strains. Eur J Pharmacol. 2009, 602, 306-15

Breuer M.E, Chan J.S, Oosting R.S, Groenink L, Korte S.M, Campbell U, Schreiber R, Hanania T, Snoeren E.M, Waldinger M, Olivier B.
The triple monoaminergic reuptake inhibitor DOV 216,303 has antidepressant effects in the rat olfactory bulbectomy model and lacks sexual side effects. Eur Neuropsychopharmacol 2008, 18, 908-16.

Savelieva K.V, Zhao S, Pogorelov V.M, Rajan I, Yang Q, Cullinan E, Lanthorn T.H.
Genetic disruption of both tryptophan hydroxylase genes strongly reduces serotonin in the brain and affects behavior in models sensitive to antidepressants. PLoS One 2008, 3(10), e3301.

Foreman M.M, Hanania T, Stratton S.C, Wilcox K.S, White H.S, Stables J.P, Eller M.
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity. Pharmacol Biochem Behav 2008, 89, 523-34.

 

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