Auditory Evoked Potentials

PsychoGenics offers a variety of Auditory Evoked Potentials (AEPs) as translatable biomarkers. AEPs are a derived from averaging the continuously-recorded EEG activity around the presentation of a time-locked auditory (tonal) stimulus. AEPs are characteristically changed in neuropsychiatric and neurodevelopmental disorders and can be pharmacologically manipulated.

We have developed Mismatch Negativity (MMN), the loudness dependence of auditory evoked potentials (LDAEP), the Many Standards Control (MSC), and P50-N100 auditory sensory gating paradigms based off of clinical AEP protocols. We are developing the Gamma-band Auditory Steady-State Response (ASSR), the oddball paradigm to elicit P3a (correlated to the involuntary shift of attention to changes in the environment), and are planning to develop P3b (P300) and Error-Related Negativity (ERN), which are cognitive event-related potentials (ERP) whose amplitudes differ dependant upon the success or failure of an action.

Mismatch Negativity (MMN) in rats

  • MMN is a key translatable biomarker for the study of auditory sensory dysfunction in schizophrenia and other neuropsychiatric disorders
  • MMN reflects pre-attentive processing and is elicited by an oddball paradigm in which different, deviant (DEV) tonal stimuli occur infrequently & unexpectedly within a sequence of repetitive identical tonal stimuli (‘standards’, STD).
  • We have established MMN in Sprague-Dawley (SD), Wistar and Wistar Kyoto (WKY) rats using oddball parameters adapted from clinical protocols
  • PsychoGenics can examine the effect of treatments designed to improve or disrupt MMN.

Auditory Evoked

  • PsychoGenics
  • 765 Old Saw Mill River Road, Tarrytown, NY 10591
  • tel: (914) 406-8019
  • fax: (914) 593-0645