PsychoGenics offers a variety of Auditory Evoked Potentials (AEPs) as translatable biomarkers. AEPs are a derived from averaging the continuously-recorded EEG activity around the presentation of a time-locked auditory (tonal) stimulus. AEPs are characteristically changed in neuropsychiatric and neurodevelopmental disorders and can be pharmacologically manipulated.
We have developed Mismatch Negativity (MMN), the loudness dependence of auditory evoked potentials (LDAEP), the Many Standards Control (MSC), and P50-N100 auditory sensory gating paradigms based off of clinical AEP protocols. We are developing the Gamma-band Auditory Steady-State Response (ASSR), the oddball paradigm to elicit P3a (correlated to the involuntary shift of attention to changes in the environment), and are planning to develop P3b (P300) and Error-Related Negativity (ERN), which are cognitive event-related potentials (ERP) whose amplitudes differ dependant upon the success or failure of an action.
Mismatch Negativity (MMN) in rats